J Edwin Blalock Selected Research

Glycine (Aminoacetic Acid)

11/2019	The matrikine acetyl-proline-glycine-proline and clinical features of COPD: findings from SPIROMICS.
11/2019	Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-induced Emphysema.
11/2018	The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.
1/2017	The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.
3/2016	Disease phenotyping in chronic obstructive pulmonary disease: the neutrophilic endotype.
12/2015	A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.
10/2015	A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.
7/2014	An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.
4/2014	Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease.
12/2013	Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations.

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J Edwin Blalock Research Topics

Disease

29	Inflammation (Inflammations) 01/2021 - 03/2006
21	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 06/2008
9	Lung Diseases (Lung Disease) 01/2022 - 04/2008
7	Pneumonia (Pneumonitis) 01/2021 - 10/2008
7	Cystic Fibrosis (Mucoviscidosis) 01/2020 - 10/2008
7	Emphysema 11/2019 - 09/2008
4	Disease Progression 07/2014 - 01/2007
3	Chronic Bronchitis 01/2019 - 10/2015
3	Respiratory Syncytial Virus Infections 10/2015 - 04/2014
3	Infections 07/2015 - 01/2007
2	Hyperoxia 01/2020 - 01/2018
2	Acute Lung Injury 11/2018 - 01/2009
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 11/2018 - 01/2015
2	Asthma (Bronchial Asthma) 01/2018 - 08/2003
2	Bronchiolitis 01/2016 - 04/2009
2	Neoplasms (Cancer) 05/2015 - 01/2007
1	Dry Eye Syndromes (Dry Eye Syndrome) 01/2020
1	Diarrhea 11/2019
1	Respiratory Hypersensitivity 01/2018
1	Bronchopulmonary Dysplasia 01/2018
1	Fibrosis (Cirrhosis) 11/2017
1	Cardiovascular Diseases (Cardiovascular Disease) 01/2017
1	Pathologic Processes 03/2016
1	Airway Obstruction (Choking) 01/2016
1	Metaplasia 01/2016
1	Hyperplasia 01/2016
1	Genetic Predisposition to Disease (Genetic Predisposition) 01/2016
1	Cough 01/2016
1	Atherosclerosis 05/2015
1	Skin Diseases (Skin Disease) 05/2015
1	Colitis 04/2014
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2014
1	Pancreatitis 12/2013
1	Male Infertility (Male Sterility) 12/2013
1	Cachexia 12/2013
1	Chronic Disease (Chronic Diseases) 01/2013
1	Lyme Disease (Disease, Lyme) 02/2011

Drug/Important Bio-Agent (IBA)

12	Glycine (Aminoacetic Acid)FDA LinkGeneric 11/2019 - 03/2010
12	Proline (L-Proline)FDA Link 11/2019 - 03/2010
11	CollagenIBA 12/2015 - 04/2008
11	Biomarkers (Surrogate Marker)IBA 06/2015 - 10/2003
10	SmokeIBA 11/2019 - 10/2010
8	Matrix Metalloproteinases (MMPs)IBA 07/2015 - 01/2007
6	Chemotactic FactorsIBA 11/2019 - 04/2008
6	Peptides (Polypeptides)IBA 11/2019 - 08/2003
5	Prolyl OligopeptidasesIBA 01/2021 - 04/2008
5	Proteins (Proteins, Gene)FDA Link 07/2015 - 08/2003
4	ElastinIBA 01/2021 - 04/2008
4	leukotriene A4 hydrolaseIBA 01/2020 - 07/2014
4	Peptide Hydrolases (Proteases)FDA Link 03/2016 - 01/2007
4	Biological ProductsIBA 10/2015 - 01/2007
4	Matrix Metalloproteinase 9 (Gelatinase B)IBA 10/2015 - 01/2007
3	Leukocyte Elastase (Neutrophil Elastase)IBA 01/2022 - 04/2014
3	prolyl-glycyl-prolineIBA 01/2020 - 06/2015
3	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 11/2019 - 12/2013
3	EnzymesIBA 01/2016 - 02/2011
3	Peroxidase (Myeloperoxidase)IBA 04/2014 - 05/2009
3	VaccinesIBA 03/2007 - 02/2003
2	Threonine (L-Threonine)FDA Link 11/2019 - 09/2008
2	Arginine (L-Arginine)FDA Link 11/2019 - 09/2008
2	Azithromycin (Zithromax)FDA LinkGeneric 03/2016 - 12/2013
2	RoflumilastIBA 03/2016 - 10/2015
2	Acrolein (Aqualin)IBA 12/2015 - 07/2014
2	AminopeptidasesIBA 07/2014 - 10/2010
2	CytokinesIBA 02/2011 - 07/2008
2	HMGB1 Protein (HMG1)IBA 03/2010 - 10/2008
2	Metalloproteases (Metalloproteinases)IBA 05/2009 - 04/2008
1	Ophthalmic Solutions (Eye Drops)IBA 01/2020
1	Nerve Growth Factor (NGF)IBA 01/2020
1	Anti-Citrullinated Protein AntibodiesIBA 01/2020
1	Immunoglobulins (Immunoglobulin)IBA 01/2020
1	Chloride Channels (Chloride Channel)IBA 11/2019
1	GoldIBA 11/2019
1	peptide LIBA 11/2019
1	IntegrinsIBA 10/2019
1	LipopolysaccharidesIBA 11/2018
1	Leukotriene B4IBA 01/2018
1	MicroRNAs (MicroRNA)IBA 01/2018
1	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 11/2017
1	Endothelin-1 (Endothelin 1)IBA 01/2017
1	Doxycycline (Periostat)FDA LinkGeneric 01/2017
1	ChemokinesIBA 01/2017
1	Interleukin-8B ReceptorsIBA 01/2017
1	Pharmaceutical PreparationsIBA 03/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2016
1	AldehydesIBA 12/2015
1	SootIBA 10/2015
1	Messenger RNA (mRNA)IBA 07/2015
1	Small Interfering RNA (siRNA)IBA 07/2015
1	Peptide FragmentsIBA 05/2015
1	cadherin 5IBA 01/2015
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 04/2014
1	Dextrans (Dextran)FDA Link 04/2014
1	Tissue Inhibitor of Metalloproteinase-1IBA 04/2014
1	MacrolidesIBA 12/2013
1	ChloridesIBA 12/2013
1	N-acetyl-proline-glycine-prolineIBA 10/2011

Therapy/Procedure

8	Therapeutics 01/2022 - 03/2007
1	Duration of Therapy 12/2013
1	Lung Transplantation 04/2009